Journal article
The use of urinary lateral-flow lipoarabinomannan assays for TB diagnosis in children
I Sabi, L Olbrich, W Olomi, A Mfinanga, HJ Zar, MP Nicol, Z Franckling-Smith, C Khosa, D Banze, M Nliwasa, EL Corbett, R Semphere, VP Verghese, JS Michael, L Larsson, SM Graham, R Song, P Nabeta, A Trollip, M Hoelscher Show all
Ijtld Open | Published : 2026
Open access
Abstract
BACKGROUND: Detection of lipoarabinomannan (LAM) in urine is a promising non-sputum-based test for TB. We aimed to evaluate Fujifilm SILVAMP TB-LAM (FujiLAM) for the diagnosis of TB in children, using AlereLAM as a comparator. METHODS: Between January 2019 to July 2021, children and young adolescents with presumptive TB disease were enrolled in five countries as part of the RaPaed-TB study. Standardised microbiological, radiologic, and clinical data were used to define TB category following published consensus criteria. FujiLAM and AlereLAM were performed on a single urine sample at enrolment. RESULTS: Of 975 children enrolled, 818 (83.9%) had FujiLAM results available. Median age was 5.5 ye..
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